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Alemtuzumab in chronic lymphocytic leukemia: final results of a large observational multicenter study in mostly pretreated patients

✍ Scribed by Fiegl, M.; Stauder, R.; Steurer, M.; Mian, M.; Hopfinger, G.; Brychtova, Y.; Skrabs, C.; Zabernigg, A.; Schmid, F.; Haslbaur, F.; Winder, G.; Walder, A.; Lang, A.; Voskova, D.; Greil, R.; Mayer, J.; Gastl, G.


Book ID
121574788
Publisher
Springer
Year
2013
Tongue
English
Weight
300 KB
Volume
93
Category
Article
ISSN
0939-5555

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## Abstract ## BACKGROUND. In previous studies, alemtuzumab demonstrated considerable activity in patients with previously treated B‐cell chronic lymphocytic leukemia (CLL), including fludarabine‐refractory disease. In this retrospective study, the authors evaluated the benefit of alemtuzumab mono

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## Purpose The phase II CLL2H trial evaluated safety and efficacy of subcutaneous alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia (CLL). Clinical and biologic markers were evaluated for their impacts on outcome. ## Patients and Methods One hundred nine patients