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Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblasts

✍ Scribed by Kyoe Tanaka; Naoto Ashizawa; Hiroaki Kawano; Osami Sato; Shinji Seto; Eijun Nishihara; Hideyuki Terazono; Shojiro Isomoto; Kazuyuki Shinohara; Katsusuke Yano

Publisher
Springer
Year
2007
Tongue
English
Weight
385 KB
Volume
22
Category
Article
ISSN
0910-8327

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## Abstract The IGF‐II/mannose 6‐phosphate receptor (IGF‐IIR/Man‐6‐P) up‐regulation correlates with heart disease progression and its signaling cascades directly trigger pathological cardiac hypertrophy, fibrosis, and cardiomyocytes apoptosis. IGF‐IIR gene expression/ suppression is able to prevent