Aldose reductase regulates TNF-α-induced inducible nitric oxide synthase expression in human mesangial cells
✍ Scribed by Jingjing Zhao; Tao Jiang; Hui Li; Yuejuan Zhang; Nong Zhang
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 446 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-4851
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## Abstract Tumor necrosis factor‐α (TNF‐α) is a pleiotropic cytokine produced by activated macrophages. Nitric oxide (NO) is a highly reactive nitrogen radical implicated in inflammatory responses. We investigated the signaling pathway involved in inducible nitric oxide synthase (iNOS) expression
Astroglia and microglia, the most numerous cells in the central nervous system (CNS), have been shown to produce the inducible nitric oxide synthase (iNOS) and tumor necrosis factor-a (TNF-a) upon stimulation with the cytokines IFN-y, IL-lp, or bacterial lipopolysaccharides (LPS). However, it is not