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Aldose reductase inhibition by 2,4-oxo and thioxo derivatives of 1,2,3,4-tetrahydroquinazoline

✍ Scribed by Florence Billon; Chantal Delchambre; Alix Cloarec; Eric Sartori; Jean-Marie Teulon


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
639 KB
Volume
25
Category
Article
ISSN
0223-5234

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## Abstract The cyclization of phenacyl anthranilate has been studied with the aim to develop the synthesis of 2‐(2′‐aminophenyl)‐4‐phenyloxazole. However, a different course of the reaction than expected was observed. 2‐Phenyl‐2‐hydroxymethyl‐4‐oxo‐1,2,3,4‐tetrahydroquinazoline (**3a**) was formed