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Aldol addition reactions of chiral crotonate imides

✍ Scribed by David A. Evans; Eric B. Sjogren; Javier Bartroli; Robert L. Dow

No coin nor oath required. For personal study only.

✦ Synopsis

Aldol addition reaction of the crotonate imides 1 and 2 affords the adducts 3 and 4 with high diastereoselection.

Subsequent removal of the chiral auxiliary can be effected in good yield to provide a number of synthetically useful intermediates.

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