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Aldehyde dehydrogenase in alcoholic subjects

✍ Scribed by Kelvin R. Palmer; William J. Jenkins

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
412 KB
Volume
5
Category
Article
ISSN
0270-9139

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✦ Synopsis

Hepatic aldehyde dehydrogenase activity is depressed in alcoholic liver disease and may account for the observation that alcoholics develop high blood acetaldehyde concentrations following ethanol. To determine whether this is a specific defect in alcoholics, aldehyde dehydrogenase was studied in liver tissue obtained from three groups of subjects. Group I comprised 30 patients with alcoholic liver disease, Group I1 consisted of eight subjects with liver disease unrelated to alcohol abuse and Group I11 was a control group of 10 individuals with no significant liver disease. Mean hepatic aldehyde dehydrogenase activity was significantly lower in Group I than in Groups 11 or I11 [4.9 f 0.6 (mean f S.E.), compared to 10.2 f 1.8 and 12.4 f 1.1 nmoles of acetaldehyde oxidized per min . mg of protein, respectively]. Aldehyde dehydrogenase activity in Group I1 was relatively

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