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Alcoholism and risk for endometrial cancer

✍ Scribed by Elisabete Weiderpass; Weimin Ye; Lorelei A. Mucci; Olof Nyrén; Dimitrios Trichopoulos; Harri Vainio; Hans-Olov Adami


Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
41 KB
Volume
93
Category
Article
ISSN
0020-7136

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✦ Synopsis


Endogenous estrogens increase the risk of endometrial cancer and are also elevated among women with high alcoholic intake. It is incompletely known, however, whether alcohol intake in general and alcohol abuse in particular increases risk for endometrial cancer. We thus analyzed prospectively the risk for endometrial cancer among 36,856 women hospitalized with alcoholism between 1965 and 1994 through linkages between several national Swedish registers. Compared with the general population, women who were alcoholics had an overall 24% lower risk of developing endometrial cancer, a finding challenging our a priori hypothesis. However, among women below the age of 50 years at follow-up, the mean age of menopause among Swedish women, the risk was 70% higher, whereas the risk among women aged 50 years or more at follow-up was 40% lower compared with the general population. Hence, the effect of alcoholism on endometrial cancer appears to be age dependent.


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