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Alcohol metabolism inDrosophila melanogaster: Uselessness of the most active aldehyde oxidase produced by the Aldox locus

✍ Scribed by Jean David; Charles Bocquet; Jeannine Herrewege; Pierre Fouillet; Marie-Françoise Arens

Publisher: Springer
Year: 1978
Tongue: English
Weight: 423 KB
Volume: 16
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00484078

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✦ Synopsis

Alcohol dehydrogenase is necessary for ethanol detoxification and metabolic utilization. It has been generally assumed that aldehyde oxidase (AO) produced by the Aldox locus (3-56.7) is necessary for a further transformation of acetaldehyde into acetate. We find that various mutant strains (ma-l or Aldoxn) which do not produce an active enzyme show about the same tolerance to alcohol as do wild strains. This physiological paradox is probably to be explained by the discovery of another locus (not localized) which produced a small amount of AO in all tested strains. The adaptive significance of the genetically polymorphic Aldox locus is probably to be looked for in physiological pathways other than ethanol metabolism.

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