Two types of factors can theoretically modulate alcohol metabolism toward increased acetaldehyde production. These factors are the following: (a) individual, genetically determined isoenzymes with distinct catalytic properties, and (b) modifications of enzyme activity induced by alcohol itself or li
Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism
โ Scribed by Holly R. Thomasson; David W. Crabb; Howard J. Edenberg; Ting-Kai Li
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 586 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0001-8244
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๐ SIMILAR VOLUMES
Liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), the principal enzymes responsible for the oxidation of ethanol, are polymorphic at theADH2, ADH3 andALDH2 loci in human beings. Our previous studies have shown that, compared with nonalcoholic individuals, Chinese alcoholic patient
## Abstract In our previous study, we found that polymorphisms of alcohol and aldehyde dehydrogenase (__ADH1B__ and __ALDH2__) are important risks for esophageal squamous cell carcinoma in a Taiwanese population. In this study, we increased the sample size to investigate the modifying effect of lif
Little is known about factors determining individual susceptibility to the physical complications of alcohol abuse but genetically determined differences in ethanol metabolism may be important. The oxidative metabolism of alcohol is catalyzed by alcohol and aldehyde dehydrogenase. Polymorphisms have