Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function

Alterations of RB1, p53 and Wnt pathways

Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis

✍ Yoshihiro Edamoto; Akira Hara; Wojciech Biernat; Luigi Terracciano; Gieri Cathom 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 259 KB 👁 1 views

## Abstract Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B~1~ exposure. While the G→T __p53__ mutation at codon 249 has been identified as a genetic hallmark o