Alane — A novel way to reduce phosphine oxides

✍ Scribed by Sara Griffin; Lucy Heath; Paul Wyatt

• Book ID: 104259321
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 96 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00748-5

✦ Synopsis

The reduction of phosphine oxides to phosphines is an important reaction in organic chemistry and there are several methods available. Many of these methods have drawbacks of one kind or another. Any research worker who has reduced a phosphine oxide to a phosphine will be familiar with the small amount of reoxidation that always seems to accompany an aqueous workup. 1 However, an aqueous workup is essential in the case of reductions with HSiC13 or Si2C162, 3 and is also necessary when LiAIH4, or one of its variants, 4 is used as the reducing agent. We have previously found the methodology developed by Lawrence et al. 1 to be excellent when a derivative phosphonium salt is made from the phosphine in situ but otherwise