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Alagille syndrome notches up mutations in Jagged 1


Book ID
114382027
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
512 KB
Volume
3
Category
Article
ISSN
1357-4310

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## Communicated by Riccardo Fodde Alagille syndrome (AGS) is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region. The Jagged-1 (JAG1) gene, which encodes a ligand of Notch, has recently been found mutated in AGS. In th