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Akt2 expression is associated with good long-term prognosis in oestrogen receptor positive breast cancer

✍ Scribed by Fohlin, Helena; Pérez-Tenorio, Gizeh; Fornander, Tommy; Skoog, Lambert; Nordenskjöld, Bo; Carstensen, John; Stål, Olle

Book ID
121989269
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
568 KB
Volume
49
Category
Article
ISSN
0959-8049

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Akt/PKB is a serine/threonine kinase that plays an important role in survival when cells are exposed to different apoptotic stimuli. Aberrant activation of Akt/PKB in breast carcinoma is associated with poor prognosis and resistance to endocrine therapy and chemotherapy. The Akt signaling pathway cu