ฮฒ-Catenin is a key protein in the canonical Wnt signaling pathway and in many cancers alterations in transcriptional activity of its components are observed. This pathway is up-regulated by the protein kinase CK2, but the underlying mechanism of this change is unknown. It has been demonstrated that
โฆ LIBER โฆ
Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity
โ Scribed by Masao Murakami; Keiichiro Kataoka; Shigetomo Fukuhara; Osamu Nakagawa; Hiroki Kurihara
- Book ID
- 110915185
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 370 KB
- Volume
- 271
- Category
- Article
- ISSN
- 1432-1327
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## Abstract Rac1, a member of the Rho family GTPases, participates in a variety of cellular functions including lamellipodia formation, actin cytoskeleton organization, cell growth, apoptosis, and neuronal development. Recent studies have implicated Rac1 in cytoskeletal abnormalities, production of