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AID-Dependent Generation of Resected Double-Strand DNA Breaks and Recruitment of Rad52/Rad51 in Somatic Hypermutation

✍ Scribed by Hong Zan; Xiaoping Wu; Atsumasa Komori; William K. Holloman; Paolo Casali


Book ID
117723394
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
790 KB
Volume
18
Category
Article
ISSN
1074-7613

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## Abstract Rad51‐mediated homologous recombination (HR) is essential for maintenance of genome integrity. The Xrcc3 protein functions in HR DNA repair, and studies suggest it has multiple roles at different stages in this pathway. Defects in vertebrate __XRCC3__ result in elevated levels of sponta