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AHindIII/BglII dystrophin gene polymorphism in the African-American population

โœ Scribed by Thomas W. Prior; Audrey C. Papp; Pamela J. Snyder; Arthur H. M. Burghes; Brian H. Wallace

Publisher
Springer
Year
1992
Tongue
English
Weight
263 KB
Volume
89
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

We describe a common dystrophin gene polymorphism in the black population that alters both HindIII and BglII restriction sites.

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Duchenne muscular dystrophy and its allelic disorder Becker muscular dystrophy are among the most common hereditary human pathologies (1:3500). Two thirds of the genomic alterations responsible for these diseases involve gross gene rearrangements such as deletions, and less frequently duplications.