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Ah-receptor-independent stimulation of hepatoma 27 culture cell proliferation by polycyclic aromatic hydrocarbons

✍ Scribed by M. S. Volkov; N. A. Bolotina; V. A. Evteev; V. A. Koblyakov

Book ID: 114988450
Publisher: Springer
Year: 2012
Tongue: English
Weight: 229 KB
Volume: 77
Category: Article
ISSN: 0006-2979
DOI: 10.1134/s0006297912020125

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## Abstract There is significant human exposure to polycyclic aromatic hydrocarbons (PAHs), many of which are potent carcinogens in laboratory animals and are suspected human carcinogens. The PAHs are bioactivated by cytochrome P450 (CYP)1A1/1B1 enzymes to reactive intermediates that bind to DNA, a