Agrochemicals, α-Synuclein, and Parkinson’s Disease
✍ Scribed by Silva, Blanca A.; Breydo, Leonid; Fink, Anthony L.; Uversky, Vladimir N.
- Book ID
- 115451171
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 327 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0893-7648
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## Abstract Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. α‐Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, a
The aggregation of normally soluble a-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of Parkinson's disease. Oxidative stress is believed to be a contributing factor in this disorder. Because it lacks Trp and Cys residues, mild oxidation of a-synu