Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan
✍ Scribed by Takekazu Onda; Tadao Tanaka; Osamu Takeda; Michihiro Kitagawa; Yoshinori Kuwabara; Hiroyuki Yamamoto; Kazuso Iinuma; Katsunori Shimomura
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 96 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0197-3851
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✦ Synopsis
Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r=0•98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme. 1998 John Wiley & Sons, Ltd.