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Agouti-related protein: More than a melanocortin-4 receptor antagonist?

✍ Scribed by Lynn E. Pritchard; Anne White


Book ID
116830651
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
249 KB
Volume
26
Category
Article
ISSN
0196-9781

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✍ Andrzej M. Wilczynski; Christine G. Joseph; Carrie Haskell-Luevano 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract Agouti‐related protein (AGRP) is an endogenous antagonist of the melanocortin‐3 and ‐4 (MC3R and MC4) G‐protein coupled receptors. The 87–132 amino acid C‐terminal domain of hAGRP possesses five disulfide bridges and a well‐defined three‐dimensional structure that displays full biologic