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Agoram B, Aoki K, Sameer Doshi, Gegg C, Jang G, Molineux G, Narhi L, Elliott S. 2008. Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role. J Pharm Sci 98: 2198–2211

✍ Scribed by Balaji Agoram; Ken Aoki; Sameer Doshi; Colin Gegg; Graham Jang; Graham Molineux; Linda Narhi; Steve Elliott

Book ID: 102398599
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 72 KB
Volume: 98
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.21905

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✦ Synopsis

In the original version of this article, there was an error in the caption for Figure 2. The figure is reproduced below with the corrected caption. We regret any confusion this may have caused.

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Investigation of the effects of altered

Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role

✍ Balaji Agoram; Ken Aoki; Sameer Doshi; Colin Gegg; Graham Jang; Graham Molineux; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB

Erythropoietin (EPO) receptor-mediated endocytosis and degradation in the bone marrow has been hypothesized to be the major clearance pathway of erythropoiesis-stimulating agents (ESA). We investigated the role of this pathway in ESA clearance by determining the pharmacokinetic profiles after intrav