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Agonist specific desensitization of leukotriene C4-stimulated PGI2 biosynthesis in human endothelial cells

✍ Scribed by Christopher W. Benjamin; Nancy K. Hopkins; Thomas D. Oglesby; Robert R. Gorman

Book ID
115757115
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
394 KB
Volume
117
Category
Article
ISSN
0006-291X

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Leukotriene C 4 is an arachidonic acid metabolite and an important mediator of inflammation and anaphylaxis that is known to induce production of prostacyclin in endothelial cells. The goal of this study was to examine the signal transduction mechanisms activated by leukotriene C 4 stimulation. Form