Receptor trafficking induced by μ-opioid
✍
Yan Zhang; Wei Xiong; Xiaojing Lin; Xiang Ma; Long-Chuan Yu
📂
Article
📅
2009
🏛
Elsevier Science
🌐
English
⚖ 188 KB
Opiates, including morphine, are widely used drugs for antinociception in clinics. Prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. One of the mechanisms for the development of tolerance and dependence is implicated to be opioi