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Agonist-independent inactivation and agonist-induced desensitization of the G protein-activated K+channel (GIRK) inXenopusoocytes

✍ Scribed by Dmitry Vorobiov; G. Levin; Ilana Lotan; N. Dascal

Book ID
106111468
Publisher
Springer
Year
1998
Tongue
English
Weight
857 KB
Volume
436
Category
Article
ISSN
0031-6768

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While opening of cardiac muscarinic K+ channels is mediated by a guanine nucleotide-binding protein, GK, and normally requires both ACh and cytosolic GTP, we demonstrate that in the absence of agonist and G-nucleotides guinea-pig atrial muscarinic K+ channels are activated by cytosolic ATP (K50 = 22