Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants

Ebselen sensitizes glioblastoma cells to

Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFα)-induced apoptosis through two distinct pathways involving NF-κB downregulation and Fas-mediated formation of death inducing signaling complex

✍ Vivek Sharma; Richa Tewari; Ugir Hossain Sk; Christy Joseph; Ellora Sen 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 343 KB

## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl