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Agonist and antagonist opioid activity of axial and equatorial conformations of S-methyl- and S-allyl-morphinans

✍ Scribed by Simon Lemaire; Bernard Belleau; François B. Jolicoeur


Book ID
115889339
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
740 KB
Volume
258
Category
Article
ISSN
0014-2999

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## Abstract Several morphinanone agonists differently substituted at C(3), C(4), C(5) and C (14) and antagonists of the 4‐hydroxy and 3, 4‐dimethoxy series were prepared by conventional chemistry. It was demonstrated that the oxygenation pattern in the bay‐area, encompassing C(3) and C(4), is impor