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Agmatine protects cultured retinal ganglion cells from tumor necrosis factor-alpha-induced apoptosis

✍ Scribed by Samin Hong; Chan Yun Kim; Jong Eun Lee; Gong Je Seong


Book ID
116719481
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
581 KB
Volume
84
Category
Article
ISSN
0024-3205

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Adenoviral-mediated transfer of ciliary neurotrophic factor (CNTF) to the retina rescued retinal ganglion cells (RGCs) from axotomy-induced apoptosis, presumably via activation of the high affinity CNTF receptor alpha (CNTFRalpha) expressed on RGCs. CNTF can also activate astrocytes, via its low aff