✦ LIBER ✦

Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

✍ Scribed by Cynthia C. Sprenger; Stephen R. Plymate; May J. Reed

Book ID: 102270970
Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 198 KB
Volume: 127
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.25615

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✦ Synopsis

Abstract

Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.

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