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Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

โœ Scribed by Peizhong Mao; P. Hemachandra Reddy


Book ID
116271036
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
480 KB
Volume
1812
Category
Article
ISSN
0925-4439

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and cognition and by senile plaques and neurofibrillary tangles in brain. Amyloid-beta peptide, particularly the 42-amino-acid peptide (Abeta(1-42)), is a principal component of senile plaques and is