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Aging alters acute apoptotic response to azoxymethane in the colon of rats

โœ Scribed by Youngjoo Kwon; Bernadene A. Magnuson

Book ID
113615043
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
713 KB
Volume
42
Category
Article
ISSN
0531-5565

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Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours
โœ Ying Hu; Richard K. Le Leu; Graeme P. Young ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 168 KB

## Abstract Acute apoptotic response to genotoxic carcinogens (AARGC) might be important for controlling the consequences of mutational load in the colon. It has been shown to occur in parallel with activation of DNA repair mechanisms. Inadequate AARGC might allow development of mutated clones with