Aging Affects Epidermal Growth Factor Receptor Phosphorylation and Traffic Kinetics
β Scribed by Wende R. Reenstra; Mina Yaar; Barbara A. Gilchrest
- Book ID
- 115602477
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 169 KB
- Volume
- 227
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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The receptor for epidermal growth factor (EGF) is a glycosylated transmembrane phosphoprotein that exhibits EGF-stimulable protein tyrosine kinase activity. On EGF stimulation, the receptor undergoes a self-phosphorylation reaction at tyrosine residues located primarily in the extreme carboxyl-termi
## Abstract Identifying proteins of signaling networks has received much attention, because an array of biological processes are entirely dependent on protein crossβtalk and proteinβprotein interactions. Protein posttranslational modifications (PTM) add an additional layer of complexity, resulting