Aggregation properties of GD1b, II3Neu5Ac2GgOse4Cer, and of GD1b-lactone, II3[α-Neu5Ac-(2→8, 1→9)-α-Neu5Ac]GgOse4Cer, in aqueous solution
✍ Scribed by Laura Cantu'; Mario Corti; Riccardo Casellato; Domenico Acquotti; Sandro Sonnino
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 546 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
The relevance of the presence of an inner ester in the oligosaccharide chain on the aggregative properties of gangliosides is investigated. Micellar molecular weight and hydrodynamic radius of natural GDI b and of semisynthetic GDI b-lactone are measured by the laser light scattering technique. The presence of the lactone ring causes an increase of 36% for the molecular weight and 16% for the hydrodynamic radius. Measurements on mixtures of GDIb and GDlb-lactone show that mixed micelles are formed with microdomain structure. The results are interpreted in terms of the geometrical packing model for the aggregation of amphiphilic molecules and are correlated to membrane processes.