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Aggregation of recombinant human growth hormone induced by phenolic compounds

✍ Scribed by Yuh-Fun Maa; Chung C. Hsu

Book ID
113368530
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
944 KB
Volume
140
Category
Article
ISSN
0378-5173

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Aggregation of recombinant therapeutic protein products is a concern due to their potential to induce immune responses. We examined the immunogenicity of protein aggregates in commercial formulations of recombinant human growth hormone produced by freeze-thawing or agitation, two stresses commonly e