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Aggregation of Normal and Sickle Hemoglobin in High Concentration Phosphate Buffer

โœ Scribed by Chen, Kejing; Ballas, Samir K.; Hantgan, Roy R.; Kim-Shapiro, Daniel B.

Book ID
119918850
Publisher
Biophysical Society
Year
2004
Tongue
English
Weight
347 KB
Volume
87
Category
Article
ISSN
0006-3495

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Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,