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Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

โœ Scribed by DiFiglia, M.


Book ID
111891803
Publisher
American Association for the Advancement of Science
Year
1997
Tongue
English
Weight
654 KB
Volume
277
Category
Article
ISSN
0036-8075

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Huntingtin, the protein product of the Huntington's disease (HD) gene, is expressed with an expanded polyglutamine domain in the brain and in nonneuronal tissues in patients with HD. Huntingtin-associated protein 1 (HAP-1), a brain-enriched protein, interacts preferentially with mutant huntingtin an