Aggregation of cell surface receptors by multivalent ligands
โ Scribed by Catherine A. Macken; Alan S. Perelson
- Book ID
- 104698347
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 324 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0303-6812
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Processes such as cell-cell recognition and the initiation of signal transduction often depend on the formation of multiple receptor-ligand complexes at the cell surface. Synthetic multivalent ligands are unique probes of these complex cell-surface-binding events. Multivalent ligands can be used as
## Abstract We present a model to describe the equilibrium binding properties for the attachment of multivalent ligands to mobile receptors in membranes. The interaction is assumed to be governed by two inherently different association constants. The first of these controls the initial attachment o