Aggregate formation and surface activity of partially deacetylated water-soluble chitin
β Scribed by Jing Wang; Changsheng Liu; Ping Chi
- Book ID
- 119892620
- Publisher
- Springer Netherlands
- Year
- 2008
- Tongue
- English
- Weight
- 163 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0922-6168
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The objective of this study was to propose novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan (NLC-PDSC) as an efficient ocular delivery system to improve its transcorneal penetration and precorneal retention. PDSC with a deacetylation degree of a
Diethylaminoethyl-chitin (DEAE-chitin) was synthesized by introducing DEAE groups onto the C(6)-OH in chitin. DEAE-chitin was N-deacetylated by heating in aqueous 10% sodium hydroxide containing sodium borohydride to prepare the diethylaminoethyl-chitosan (DEAE-chitosan). In addition, DEAE-chitin wa