Age-related efficiency of Ca-DTPA to reduce 141Ce retention in rats
✍ Scribed by Kargačin, B.; Kostial, K.
- Book ID
- 123429734
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 318 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0378-4274
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The influence of age on the effectiveness of chelation therapy starting 24 h after cerium administration was studied in 2- and 6-week-old rats. 141Ce was administered IP, followed after 24 and 48 h by IP administration of trisodium calcium diethylenetriaminepentaacetate (Ca-DTPA). The whole body and
Monoisoamyl (Mi-ADMS) and mono-n-hexyl (Mn-HDMS) monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were given orally or parenterally for the mobilization of inorganic mercury in suckling and older rats. Chelators were administered at a dose of 2 x 0.5 mmol kg-1 on two consecutive days 2 weeks af