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Age-related effects in T cell activation and proliferation

✍ Scribed by Lijun Song; Young Ho Kim; Rajesh K. Chopra; Jacques J. Proust; James E. Nagel; Albert A. Nordin; William H. Adler


Book ID
113371365
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
622 KB
Volume
28
Category
Article
ISSN
0531-5565

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CD4(+) T cells from old mice show defects in the activation process including deficiency in the formation of immunosynapses with antigen-presenting cells. We show that CD4(+) T cells from old mice express unusually high levels of glycosylated forms of the bulky T cell glycoprotein CD43, particularly