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Age-related distribution of endocrine cells in the human prostate: a quantitative study

✍ Scribed by S. Battaglia; A. M. Casali; A. R. Botticelli

Publisher: Springer
Year: 1994
Tongue: English
Weight: 902 KB
Volume: 424
Category: Article
ISSN: 1432-2307
DOI: 10.1007/bf00193496

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✦ Synopsis

A morphometric analysis was performed to obtain quantitative data on age-related changes in prostatic endocrine cell (PrEC) density. Sixty prostates from subjects aged 14-74 years were studied with a semi-automatic image analysis system (ASM 68K, Leitz) applied to sections immunostained for chromogranin A-reactive cells. The highest density of PrECs (0.366 cells/mm of epithelial length) was found in the 25-54 year age group, which was significantly different from that found in prostates of the younger (0.311 cells/ mm) and the older (0.261 cells/ram) age groups. The data probably reflect the higher incidence of incompletely developed glandular units in the younger group and the formation of new alveoli related to the usual glandular hyperplasia that occurs with increasing age in the older group.

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