Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)
β Scribed by Kevin C. H. Pang; Jonathan P. Miller; Ashley Fortress; J. Devin McAuley
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 332 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0161-9152
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Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of system