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Age-related differences in sensitivity to organophosphorus pesticides

โœ Scribed by Carey N Pope; Jing Liu


Book ID
117766385
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
166 KB
Volume
4
Category
Article
ISSN
1382-6689

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Chlorpyrifos (CPF), a commonly used cholinesterase-inhibiting insecticide, is lethal at much lower doses to young animals than adults. To explain this higher sensitivity in younger animals, we hypothesized that young rats have less chlorpyrifos-oxonase (CPFOase) activity than adults. To test this hy