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Age-related decrease in spontaneity observed in senescence-accelerated mice (SAMP10) and the involvement of the dopaminergic system in behavioral disorders

✍ Scribed by Hideki Takahashi; Junko Sakamoto; Hiroyuki Ohta; Masaomi Miyamoto

Book ID: 117552243
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 299 KB
Volume: 1260
Category: Article
ISSN: 0531-5131
DOI: 10.1016/s0531-5131(03)01671-6

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Twelve substrains of inbred senescence-accelerated mice (SAM) have been developed, among which the SAMP8 and SAMP10 strains show a significant age-related deterioration in learning and memory for passive and active avoidance tasks. These strains have, respectively, a low and high incidence of system