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Age-Related Decline in Activation of JNK by TCR- and CD28-Mediated Signals in Murine T-Lymphocytes

✍ Scribed by Christopher J. Kirk; Aaron M. Freilich; Richard A. Miller


Book ID
118768255
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
136 KB
Volume
197
Category
Article
ISSN
0008-8749

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Autonomous induction of proliferation, J
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Induction of proliferation in primary resting T cells requires engagement of both the antigenspecific TCR and the co-stimulatory receptor CD28. Here we report that CD28 functions as an autonomous mitogenic receptor which is mobilized by TCR signaling through cytoskeletal rearrangement. Shortcutting