✦ LIBER ✦

Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice

✍ Scribed by Makoto Takeuchi; Hiroyuki Miyazaki; Katsuku Mirokawa; Tenio Yokokura; Yasunobu Yoshikai

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 295 KB
Volume: 23
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830230637

No coin nor oath required. For personal study only.

✦ Synopsis

Age-related changes in T cell subsets were examined in intestinal intraepithelial lymphocytes (i-IEL), which contain unique T cells differentiating extrathymically. In 2-month-old mice bred under conventional condition, i -E L consisted of a large number of CD4-CDSa/a+ cells bearing either Tcell receptor (TcR)a/P or TcRylG and only a few CD4+CDSa-cells. In aged mice (6 months old and 24 months old), unique CD4+CDSa/a+ i-IEL bearing TcRdB increased in number and conversely the proportion of TcRy/G+ i-IEL was decreased. Such an increase in number of CD4+CDSa/a+ cells was detected in i-IEL from aged (14-months old) nude mice, but not in aged (14 months old) germ-free mice, suggesting that a significant fraction of TcRdP T cells such as CD4+CDSa+ i-IEL can develop along an extrathymic pathway under the influence of intestinal microflora with age.

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