Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes
✍ Scribed by S.J. Pasquaré; V.L. Gaveglio; N.M. Giusto
- Book ID
- 116178465
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 816 KB
- Volume
- 488
- Category
- Article
- ISSN
- 0003-9861
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In synaptosomes from rat cerebral cortex, the potential catalytic activity of some enzymes related to energy metabolism-namely, phosphofructokinase and citrate synthase-is not affected by aging. In contrast, the maximum velocity (Vm& of cytochrome oxidase and of pyruvate dehydrogenase decreases in a
## Abstract Insulin receptor associated with the cerebral cortex (CC) has been shown to be involved in brain cognitive functions. Furthermore, deterioration of insulin signaling has been associated with age‐related brain degeneration. We have reported previously that aging stimulates phospholipase