Age-related changes in human articular cartilage proteoglycans
โ Scribed by Michael T. Bayliss; S.Y. Ali
- Book ID
- 113214064
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 198 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0049-0172
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๐ SIMILAR VOLUMES
Biochemical and biophysical studies have demonstrated that proteoglycan monomers from immature and adult articular cartilage differ in composition and size. To investigate the structural basis of age-related differences in articular cartilage proteoglycan monomers and aggregates, we isolated and pur
We report the use of immunologic methods for detecting specific alterations in human osteoarthritic cartilage. Monoclonal antibodies with specificities for proteoglycans and link proteins have been used to define immunogenic sites in these molecules. We have identified 1 site in the protein core, 1