Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats
✍ Scribed by Makbule Aydin; Salih Cengiz; Bedia Aǧaçhan; Hülya Yilmaz; Turgay Isbir
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 151 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
In this study, age-related changes of GM1, GD1a, GT1b fractions of gangliosides were investigated in whole brain of male Wistar albino rats. Insigni®cant increases were detected in GM1 values from the third to the 24th month, whereas GD1a and GT1b concentrations of ganglioside in 24-month-old rats decreased signi®cantly as compared to 6-monthold rats. Although there were no signi®cant dierences in the GD1a/GT1b ratio of any groups, GM1/GD1a and GM1/ GT1b ratios were signi®cantly increased as compared to 6-month-old rats. The increase in the ratios of gangliosides are not due to an increase of GM1 fractions; they result from a decrease of GD1a and GT1b fractions of gangliosides. In conclusion, the concentration of ganglioside decreased with ageing.