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Age-related changes in Brain T1 are correlated with iron concentration

✍ Scribed by Robert J. Ogg; R. Grant Steen

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
473 KB
Volume
40
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Age‐related changes in brain T~1~ from 115 healthy subjects (range, 4.5–71.9 yr) were analyzed in relation to published regional brain iron concentration in cortex, caudate, putamen, and frontal white matter. The relaxation rate in these struc tures was linear with respect to iron concentration (P < 0.001). The iron relaxivity, k~1~ (s^−1^/mg iron/g wet weight), was much higher in cortex (5.5) and white matter (6.1) than in caudate (1.7) and putamen (1.0). These results are consistent with evidence that iron is an important factor in determining the relaxation properties of brain tissue. Iron relaxivity may reflect regional differences in the physical state of brain iron or in the interaction of brain iron with tissue water.

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## Abstract Temporal changes in the __T__~1~ and __T__~2~ relaxation rates (Δ__R__~1~ and Δ__R__~2~) in rat olfactory bulb (OB) and cortex were compared with the absolute manganese (Mn) concentrations from the corresponding excised tissue samples. In vivo __T__~1~ and __T__~2~ relaxation times were