Age-of-onset heterogeneity in Huntington disease families
โ Scribed by Pericak-Vance, M. A. ;Elston, R. C. ;Conneally, P. M. ;Dawson, D. V. ;Opitz, John M.
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 674 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0148-7299
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๐ SIMILAR VOLUMES
We analyzed the data on age at onset and CAG size of 319 patients clinically diagnosed with Huntington disease (HD) and 86 presymptomatic subjects recorded by four Italian Centers over the last 14 years. To overcome the problem of different CAG numbers found in each subject, also in the same family,
Previous investigators have noted that the type of sampling scheme used to study the natural history of Huntington's disease can affect the observed age of onset distribution. Simulated data are presented to demonstrate that bias is introduced when onset characteristics derived from prevalence sampl